Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers
Abstract
The synthetic polymers and their combinations were employed to retard the release of nimesulide from microcapsules. Microcapsules were prepared in different ratios of Eudragit RL 100 and hydroxy propyl methyl cellulose (HPMC) separately and in combination. All formulations of microcapsules were compressed to tablets. Dissolution of microcapsules and their tablets was performed by USP-apparatus-II in 900 mL borate buffer of pH 8.4 at 37.0 ± 0.5 ºC, at 50 rpm. In vitro kinetics was determined by various models including Zero order, First Order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell. Eudragit showed higher retarding effect over extended period of time on release of drug than HPMC alone or its combination with Eudragit.Colegio de Farmacéuticos de la Provincia de Buenos AireSimilar works
Full text
Last time updated on 04/09/2013
This paper was published in Servicio de Difusión de la Creación Intelectual.
Having an issue?
Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.